Peroxisome proliferator-activated receptor alpha (PPARalpha) is known to control fat metabolism in the liver. Accordingly, PPARalpha is highly expressed in the liver. “We are surprised to find high level of PPARalpha in the hippocampus of animal models,” said Pahan. “While PPARalpha deficient mice are poor in learning and memory, injection of PPAR to the hippocampus of PPARalpha deficient mice improves learning and memory,” said Pahan. Since PPARalpha directly controls fat metabolism, people with abdominal fat levels have depleted PPARalpha in the liver and abnormal lipid metabolism. At first, these individuals lose PPARalpha from the liver and then eventually from the whole body including the brain. Therefore, abdominal fat is an early indication of some kind of dementia later in life, according to Pahan.
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